TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial receptor that recognizes changes in the lipid microenvironment, which may occur during amyloid β (Aβ) accumulation and neuronal degeneration in Alzheimer’s disease (AD). Rare TREM2 variants that affect TREM2 function lead to an...

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發表在:J Exp Med
Main Authors: Wang, Yaming, Ulland, Tyler K., Ulrich, Jason D., Song, Wilbur, Tzaferis, John A., Hole, Justin T., Yuan, Peng, Mahan, Thomas E., Shi, Yang, Gilfillan, Susan, Cella, Marina, Grutzendler, Jaime, DeMattos, Ronald B., Cirrito, John R., Holtzman, David M., Colonna, Marco
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2016
主題:
Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854736/
https://ncbi.nlm.nih.gov/pubmed/27091843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151948
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