ApoE facilitates the microglial response to amyloid plaque pathology

One of the hallmarks of Alzheimer’s disease is the presence of extracellular diffuse and fibrillar plaques predominantly consisting of the amyloid-β (Aβ) peptide. Apolipoprotein E (ApoE) influences the deposition of amyloid pathology through affecting the clearance and aggregation of monomeric Aβ in...

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Bibliografische gegevens
Gepubliceerd in:J Exp Med
Hoofdauteurs: Ulrich, Jason D., Ulland, Tyler K., Mahan, Thomas E., Nyström, Sofie, Nilsson, K. Peter, Song, Wilbur M., Zhou, Yingyue, Reinartz, Mariska, Choi, Seulah, Jiang, Hong, Stewart, Floy R., Anderson, Elise, Wang, Yaming, Colonna, Marco, Holtzman, David M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Rockefeller University Press 2018
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881464/
https://ncbi.nlm.nih.gov/pubmed/29483128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171265
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