ApoE facilitates the microglial response to amyloid plaque pathology

One of the hallmarks of Alzheimer’s disease is the presence of extracellular diffuse and fibrillar plaques predominantly consisting of the amyloid-β (Aβ) peptide. Apolipoprotein E (ApoE) influences the deposition of amyloid pathology through affecting the clearance and aggregation of monomeric Aβ in...

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Pubblicato in:J Exp Med
Autori principali: Ulrich, Jason D., Ulland, Tyler K., Mahan, Thomas E., Nyström, Sofie, Nilsson, K. Peter, Song, Wilbur M., Zhou, Yingyue, Reinartz, Mariska, Choi, Seulah, Jiang, Hong, Stewart, Floy R., Anderson, Elise, Wang, Yaming, Colonna, Marco, Holtzman, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2018
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881464/
https://ncbi.nlm.nih.gov/pubmed/29483128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171265
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