TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial receptor that recognizes changes in the lipid microenvironment, which may occur during amyloid β (Aβ) accumulation and neuronal degeneration in Alzheimer’s disease (AD). Rare TREM2 variants that affect TREM2 function lead to an...

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Vydáno v:J Exp Med
Hlavní autoři: Wang, Yaming, Ulland, Tyler K., Ulrich, Jason D., Song, Wilbur, Tzaferis, John A., Hole, Justin T., Yuan, Peng, Mahan, Thomas E., Shi, Yang, Gilfillan, Susan, Cella, Marina, Grutzendler, Jaime, DeMattos, Ronald B., Cirrito, John R., Holtzman, David M., Colonna, Marco
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2016
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854736/
https://ncbi.nlm.nih.gov/pubmed/27091843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151948
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