In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis

BACKGROUND: The APOE4 allele variant is the strongest known genetic risk factor for developing late-onset Alzheimer’s disease. The link between apolipoprotein E (apoE) and Alzheimer’s disease is likely due in large part to the impact of apoE on the metabolism of amyloid β (Aβ) within the brain. Mani...

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Autores principales: Ulrich, Jason D, Burchett, Jack M, Restivo, Jessica L, Schuler, Dorothy R, Verghese, Philip B, Mahan, Thomas E, Landreth, Gary E, Castellano, Joseph M, Jiang, Hong, Cirrito, John R, Holtzman, David M
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
Materias:
Methodology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640999/
https://ncbi.nlm.nih.gov/pubmed/23601557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-8-13
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