Amyloid β and Alzheimer disease therapeutics: the devil may be in the details

Por Cirrito, John R., Holtzman, David M.
Publicado em 2003

Reply to Pomara and Bruno: Need for prospective, randomized clinical trial

Por Sheline, Yvette I., Cirrito, John R.
Publicado em 2011

Microbiosensor for Alzheimer’s Disease Diagnostics: Detection of Amyloid Beta Biomarkers

Por Prabhulkar, Shradha, Piatyszek, Rudolph, Cirrito, John R., Wu, Ze-zhi, Li, Chen-Zhong
Publicado em 2012

Acute stress increases interstitial fluid amyloid-β via corticotropin-releasing factor and neuronal activity

Por Kang, Jae-Eun, Cirrito, John R., Dong, Hongxin, Csernansky, John G., Holtzman, David M.
Publicado em 2007

Opposing Synaptic Regulation of Amyloid-β Metabolism by NMDA Receptors In Vivo

Por Verges, Deborah K., Restivo, Jessica L., Goebel, Whitney D., Holtzman, David M., Cirrito, John R.
Publicado em 2011

Redundant G(s)-coupled serotonin receptors regulate amyloid-β metabolism in vivo

Por Fisher, Jonathan R., Wallace, Clare E., Tripoli, Danielle L., Sheline, Yvette I., Cirrito, John R.
Publicado no Mol Neurodegener (2016)

Traumatic Brain Injury Reduces Soluble Extracellular Amyloid-β in Mice: A Methodologically Novel Combined Microdialysis- Controlled Cortical Impact Study

Por Schwetye, Katherine E., Cirrito, John R., Esparza, Thomas J., Mac Donald, Christine L., Holtzman, David M., Brody, David L.
Publicado em 2010

β-Secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice

Por Chang, Wan-Pin, Huang, Xiangping, Downs, Deborah, Cirrito, John R., Koelsch, Gerald, Holtzman, David M., Ghosh, Arun K., Tang, Jordan
Publicado em 2011

Amyloid-beta Oligomerization in Alzheimer Dementia vs. High Pathology Controls

Por Esparza, Thomas J., Zhao, Hanzhi, Cirrito, John R., Cairns, Nigel J., Bateman, Randall J., Holtzman, David M., Brody, David L.
Publicado em 2012

Role of Phosphatidylinositol Clathrin Assembly Lymphoid-Myeloid Leukemia (PICALM) in Intracellular Amyloid Precursor Protein (APP) Processing and Amyloid Plaque Pathogenesis

Por Xiao, Qingli, Gil, So-Chon, Yan, Ping, Wang, Yan, Han, Sharon, Gonzales, Ernie, Perez, Ronaldo, Cirrito, John R., Lee, Jin-Moo
Publicado em 2012

Response to Comments on “ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models”

Por Landreth, Gary E., Cramer, Paige E., Lakner, Mitchell M., Cirrito, John R., Wesson, Daniel W., Brunden, Kurt R., Wilson, Donald A.
Publicado em 2013

Characterization of a Brain Permeant Fluorescent Molecule and Visualization of Aβ Parenchymal Plaques, Using Real-Time Multiphoton Imaging in Transgenic Mice

Por Sundaram, G.S.M., Garai, Kanchan, Rath, Nigam P., Yan, Ping, Cirrito, John R., Cairns, Nigel J., Lee, Jin-Moo, Sharma, Vijay
Publicado no Org Lett (2014)

Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition

Por Liu, Chia-Chen, Hu, Jin, Zhao, Na, Wang, Jian, Wang, Na, Cirrito, John R., Kanekiyo, Takahisa, Holtzman, David M., Bu, Guojun
Publicado no J Neurosci (2017)

Characterizing the Appearance and Growth of Amyloid Plaques in APP/PS1 Mice

Por Yan, Ping, Bero, Adam W., Cirrito, John R., Xiao, Qingli, Hu, Xiaoyan, Wang, Yan, Gonzales, Ernesto, Holtzman, David M., Lee, Jin-Moo
Publicado em 2009

Neuronal Clearance of Amyloid-β by Endocytic Receptor LRP1

Por Kanekiyo, Takahisa, Cirrito, John R., Liu, Chia-Chen, Shinohara, Mitsuru, Li, Jie, Schuler, Dorothy R., Shinohara, Motoko, Holtzman, David M., Bu, Guojun
Publicado em 2013

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

Por Bero, Adam W., Yan, Ping, Roh, Jee Hoon, Cirrito, John R., Stewart, Floy R., Raichle, Marcus E., Lee, Jin-Moo, Holtzman, David M.
Publicado em 2011

Endocytosis is required for synaptic activity-dependent release of amyloid-β in vivo

Por Cirrito, John R., Kang, Jae-Eun, Lee, Jiyeon, Stewart, Floy R., Verges, Deborah K., Silverio, Luz M., Bu, Guojun, Mennerick, Steven, Holtzman, David M.
Publicado em 2008

Dynamic Analysis of Amyloid β-Protein in Behaving Mice Reveals Opposing Changes in ISF versus Parenchymal Aβ during Age-Related Plaque Formation

Por Hong, Soyon, Quintero-Monzon, Omar, Ostaszewski, Beth L., Podlisny, Daniel R., Cavanaugh, William T., Yang, Ting, Holtzman, David M., Cirrito, John R., Selkoe, Dennis J.
Publicado em 2011

Bidirectional Relationship between Functional Connectivity and Amyloid-β Deposition in Mouse Brain

Por Bero, Adam W., Bauer, Adam Q., Stewart, Floy R., White, Brian R., Cirrito, John R., Raichle, Marcus E., Culver, Joseph P., Holtzman, David M.
Publicado em 2012

Anti-Aβ single-chain antibody brain delivery via AAV reduces amyloid load but may increase cerebral hemorrhages in an Alzheimer mouse model

Por Kou, Jinghong, Kim, HongDuck, Pattanayak, Abhinandan, Song, Min, Lim, Jeong-Eun, Taguchi, Hiroaki, Paul, Sudhir, Cirrito, John R., Ponnazhagan, Selvarangan, Fukuchi, Ken-ichiro
Publicado em 2011