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Neuronal activity regulates the regional vulnerability to amyloid-β deposition

Amyloid-β (Aβ) plaque deposition in specific brain regions is a major pathological hallmark of Alzheimer’fs disease (AD). However, the mechanism underlying the regional vulnerability to Aβ deposition in AD is unknown. Herein, we provide evidence that endogenous neuronal activity regulates the region...

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Detalhes bibliográficos
Main Authors: Bero, Adam W., Yan, Ping, Roh, Jee Hoon, Cirrito, John R., Stewart, Floy R., Raichle, Marcus E., Lee, Jin-Moo, Holtzman, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102784/
https://ncbi.nlm.nih.gov/pubmed/21532579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2801
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