β-Secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice

Alzheimer disease is intimately linked to an excess amount of amyloid-β (Aβ) in the brain. Thus, therapeutic inhibition of Aβ production is an attractive clinical approach to treat this disease. Here we provide the first direct experimental evidence that the treatment of Tg2576 transgenic mice with...

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Detalles Bibliográficos
Main Authors: Chang, Wan-Pin, Huang, Xiangping, Downs, Deborah, Cirrito, John R., Koelsch, Gerald, Holtzman, David M., Ghosh, Arun K., Tang, Jordan
Formato: Artigo
Idioma:Inglês
Publicado: Federation of American Societies for Experimental Biology 2011
Assuntos:
Research Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023390/
https://ncbi.nlm.nih.gov/pubmed/21059748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-167213
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