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β-Secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice
Alzheimer disease is intimately linked to an excess amount of amyloid-β (Aβ) in the brain. Thus, therapeutic inhibition of Aβ production is an attractive clinical approach to treat this disease. Here we provide the first direct experimental evidence that the treatment of Tg2576 transgenic mice with...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Federation of American Societies for Experimental Biology
2011
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3023390/ https://ncbi.nlm.nih.gov/pubmed/21059748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-167213 |
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