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Beneficial Effects of the β-Secretase Inhibitor GRL-8234 in 5XFAD Alzheimer’s Transgenic Mice Lessen during Disease Progression
The β-secretase enzyme BACE1, which initiates the cleavage of amyloid precursor protein (APP) into the amyloid-β (Aβ) peptide, is a prime therapeutic target for Alzheimer’s disease (AD). However, recent investigations using genetic animal models raise concern that therapeutic BACE1 inhibition may en...
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| Publicado no: | Curr Alzheimer Res |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4414026/ https://ncbi.nlm.nih.gov/pubmed/25523425 |
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