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Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer’s disease transgenic mice
Mitochondrial dysfunction is an early feature of Alzheimer’s disease (AD) and may play an important role in the pathogenesis of disease. Emerging evidence indicates that amyloid-β(Aβ) peptides enter mitochondria and may thereby disrupt mitochondrial function in brains of AD patients and transgenic m...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3225635/ https://ncbi.nlm.nih.gov/pubmed/21933711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2011.09.001 |
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