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Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer’s disease transgenic mice

Mitochondrial dysfunction is an early feature of Alzheimer’s disease (AD) and may play an important role in the pathogenesis of disease. Emerging evidence indicates that amyloid-β(Aβ) peptides enter mitochondria and may thereby disrupt mitochondrial function in brains of AD patients and transgenic m...

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Detalhes bibliográficos
Main Authors: Devi, Latha, Ohno, Masuo
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225635/
https://ncbi.nlm.nih.gov/pubmed/21933711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2011.09.001
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