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Effects of BACE1 Haploinsufficiency on APP Processing and Aβ Concentrations in Male and Female 5XFAD Alzheimer Mice at Different Disease Stages
β-Site APP-cleaving enzyme 1 (BACE1) initiates the generation of amyloid-β (A β), thus representing a prime therapeutic target for Alzheimer’s disease (AD). Previous work including ours has used BACE1 haploinsufficiency (BACE1(+/−); i.e., 50% reduction) as a therapeutic relevant model to evaluate th...
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| Publicado no: | Neuroscience |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4591236/ https://ncbi.nlm.nih.gov/pubmed/26314636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2015.08.037 |
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