Anti-Aβ single-chain antibody brain delivery via AAV reduces amyloid load but may increase cerebral hemorrhages in an Alzheimer mouse model

Accumulation of amyloid β-protein (Aβ) in the brain is thought to be a causal event in Alzheimer’s disease (AD). Immunotherapy targeting Aβ holds great promise for reducing Aβ in the brain. Here, we evaluated the efficacy and safety of anti-Aβ single-chain antibody (scFv59) delivery via recombinant...

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Библиографические подробности
Главные авторы: Kou, Jinghong, Kim, HongDuck, Pattanayak, Abhinandan, Song, Min, Lim, Jeong-Eun, Taguchi, Hiroaki, Paul, Sudhir, Cirrito, John R., Ponnazhagan, Selvarangan, Fukuchi, Ken-ichiro
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3560395/
https://ncbi.nlm.nih.gov/pubmed/21709371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2011-110230
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