Muscle-directed anti-Aβ single-chain antibody delivery via AAV1 reduces cerebral Aβ load in an Alzheimer’s disease mouse model

We previously reported that anti-Aβ single-chain antibody (scFv59) brain delivery via recombinant adeno-associated virus (rAAV) was effective in reducing cerebral Aβ load in an AD mouse model without inducing inflammation. Here, we investigated the prophylactic effects and mechanism of a muscle-dire...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Yang, Junling, Pattanayak, Abhinandan, Song, Min, Kou, Jinghong, Taguchi, Hiroaki, Paul, Sudhir, Ponnazhagan, Selvarangan, Lalonde, Robert, Fukuchi, Ken-ichiro
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545079/
https://ncbi.nlm.nih.gov/pubmed/22945846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12031-012-9877-3
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller