Combined treatment of Aβ immunization with statin in a mouse model of Alzheimer’s disease

We evaluated the therapeutic efficacy of combined treatment of Aβ-immunization with simvastatin in an Alzheimer mouse model at age 22 months. DNA prime-adenovirus boost immunization induced modest anti-Aβ titers and simvastatin increased the seropositive rate. Aβ-KLH was additionally administered to...

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Autors principals: Kou, Jinghong, Song, Min, Pattanayak, Abhinandan, Lim, Jeong-Eun, Yang, Junling, Cao, Dongfeng, Li, Ling, Fukuchi, Ken-ichiro
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298635/
https://ncbi.nlm.nih.gov/pubmed/22326143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2012.01.008
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