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Acute stress increases interstitial fluid amyloid-β via corticotropin-releasing factor and neuronal activity

Aggregation of the amyloid-β (Aβ) peptide in the extracellular space of the brain is critical in the pathogenesis of Alzheimer's disease. Aβ is produced by neurons and released into the brain interstitial fluid (ISF), a process regulated by synaptic activity. To determine whether behavioral str...

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Autors principals: Kang, Jae-Eun, Cirrito, John R., Dong, Hongxin, Csernansky, John G., Holtzman, David M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1965571/
https://ncbi.nlm.nih.gov/pubmed/17551018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700148104
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