Role of Phosphatidylinositol Clathrin Assembly Lymphoid-Myeloid Leukemia (PICALM) in Intracellular Amyloid Precursor Protein (APP) Processing and Amyloid Plaque Pathogenesis

One of the pathological hallmarks of Alzheimer disease is the accumulation of amyloid plaques in the extracellular space in the brain. Amyloid plaques are primarily composed of aggregated amyloid β peptide (Aβ), a proteolytic fragment of the transmembrane amyloid precursor protein (APP). For APP to...

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Main Authors: Xiao, Qingli, Gil, So-Chon, Yan, Ping, Wang, Yan, Han, Sharon, Gonzales, Ernie, Perez, Ronaldo, Cirrito, John R., Lee, Jin-Moo
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2012
נושאים:
Neurobiology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375549/
https://ncbi.nlm.nih.gov/pubmed/22539346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.338376
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