Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis

In AD, an imbalance between Aβ production and removal drives elevated brain Aβ levels and eventual amyloid plaque deposition. APP undergoes nonamyloidogenic processing via α-cleavage at the plasma membrane, amyloidogenic β- and γ-cleavage within endosomes to generate Aβ, or lysosomal degradation in...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Xiao, Qingli, Yan, Ping, Ma, Xiucui, Liu, Haiyan, Perez, Ronaldo, Zhu, Alec, Gonzales, Ernesto, Tripoli, Danielle L., Czerniewski, Leah, Ballabio, Andrea, Cirrito, John R., Diwan, Abhinav, Lee, Jin-Moo
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556784/
https://ncbi.nlm.nih.gov/pubmed/26338325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0705-15.2015
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