Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis

In AD, an imbalance between Aβ production and removal drives elevated brain Aβ levels and eventual amyloid plaque deposition. APP undergoes nonamyloidogenic processing via α-cleavage at the plasma membrane, amyloidogenic β- and γ-cleavage within endosomes to generate Aβ, or lysosomal degradation in...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Xiao, Qingli, Yan, Ping, Ma, Xiucui, Liu, Haiyan, Perez, Ronaldo, Zhu, Alec, Gonzales, Ernesto, Tripoli, Danielle L., Czerniewski, Leah, Ballabio, Andrea, Cirrito, John R., Diwan, Abhinav, Lee, Jin-Moo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2015
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556784/
https://ncbi.nlm.nih.gov/pubmed/26338325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0705-15.2015
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