Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis

In AD, an imbalance between Aβ production and removal drives elevated brain Aβ levels and eventual amyloid plaque deposition. APP undergoes nonamyloidogenic processing via α-cleavage at the plasma membrane, amyloidogenic β- and γ-cleavage within endosomes to generate Aβ, or lysosomal degradation in...

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Publicat a:J Neurosci
Autors principals: Xiao, Qingli, Yan, Ping, Ma, Xiucui, Liu, Haiyan, Perez, Ronaldo, Zhu, Alec, Gonzales, Ernesto, Tripoli, Danielle L., Czerniewski, Leah, Ballabio, Andrea, Cirrito, John R., Diwan, Abhinav, Lee, Jin-Moo
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556784/
https://ncbi.nlm.nih.gov/pubmed/26338325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0705-15.2015
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