Receptor-associated Protein Interacts with Amyloid-β Peptide and Promotes Its Cellular Uptake

Por Kanekiyo, Takahisa, Bu, Guojun
Publicado em 2009

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease

Por Kanekiyo, Takahisa, Bu, Guojun
Publicado em 2014

ApoE and Aβ in Alzheimer’s disease: accidental encounters or partners?

Por Kanekiyo, Takahisa, Xu, Huaxi, Bu, Guojun
Publicado em 2014

Vascular hypothesis of Alzheimer’s disease: role of apoE and apoE receptors

Por Bu, Guojun, Liu, Chia-Chen, Kanekiyo, Takahisa
Publicado em 2013

LRP1 plays a major role in the amyloid-β clearance in microglia

Por N’Songo, Aurelie, Kanekiyo, Takahisa, Bu, Guojun
Publicado em 2013

Apolipoprotein E and Alzheimer disease: risk, mechanisms, and therapy

Por Liu, Chia-Chen, Kanekiyo, Takahisa, Xu, Huaxi, Bu, Guojun
Publicado em 2013

Tyrosine-based Signal Mediates LRP6 Receptor Endocytosis and Desensitization of Wnt/β-Catenin Pathway Signaling

Por Liu, Chia-Chen, Kanekiyo, Takahisa, Roth, Barbara, Bu, Guojun
Publicado em 2014

Low Density Lipoprotein Receptor-related Protein 1 Promotes Anti-apoptotic Signaling in Neurons by Activating Akt Survival Pathway

Por Fuentealba, Rodrigo A., Liu, Qiang, Kanekiyo, Takahisa, Zhang, Juan, Bu, Guojun
Publicado em 2009

Familial Frontotemporal Dementia-Associated Presenilin-1 c.548G>T Mutation Causes Decreased mRNA Expression and Reduced Presenilin Function in Knock-In Mice

Por Watanabe, Hirotaka, Xia, Dan, Kanekiyo, Takahisa, Kelleher, Raymond J., Shen, Jie
Publicado em 2012

LRP1 in Brain Vascular Smooth Muscle Cells Mediates Local Clearance of Alzheimer's Amyloid-β

Por Kanekiyo, Takahisa, Liu, Chia-Chen, Shinohara, Mitsuru, Li, Jie, Bu, Guojun
Publicado em 2012

Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Regulates the Stability and Function of GluA1 α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid (AMPA) Receptor in Neu...

Por Gan, Ming, Jiang, Peizhou, McLean, Pamela, Kanekiyo, Takahisa, Bu, Guojun
Publicado no PLoS One (2014)

Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-β Uptake

Por Kanekiyo, Takahisa, Zhang, Juan, Liu, Qiang, Liu, Chia-Chen, Zhang, Lijuan, Bu, Guojun
Publicado em 2011

Rescuing Effects of RXR Agonist Bexarotene on Aging-related Synapse Loss Depend on Neuronal LRP1

Por Tachibana, Masaya, Shinohara, Mitsuru, Yamazaki, Yu, Liu, Chia-Chen, Rogers, Justin, Bu, Guojun, Kanekiyo, Takahisa
Publicado no Exp Neurol (2015)

Differential Regulation of Amyloid-β Endocytic Trafficking and Lysosomal Degradation by Apolipoprotein E Isoforms

Por Li, Jie, Kanekiyo, Takahisa, Shinohara, Mitsuru, Zhang, Yunwu, LaDu, Mary Jo, Xu, Huaxi, Bu, Guojun
Publicado em 2012

Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway

Por Casey, Caroline S., Atagi, Yuka, Yamazaki, Yu, Shinohara, Mitsuru, Tachibana, Masaya, Fu, Yuan, Bu, Guojun, Kanekiyo, Takahisa
Publicado no J Biol Chem (2015)

Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain

Por Liu, Chia-Chen, Hu, Jin, Tsai, Chih-Wei, Yue, Mei, Melrose, Heather L., Kanekiyo, Takahisa, Bu, Guojun
Publicado no J Neurosci (2015)

Retinoic Acid Isomers Facilitate Apolipoprotein E Production and Lipidation in Astrocytes through the Retinoid X Receptor/Retinoic Acid Receptor Pathway

Por Zhao, Jing, Fu, Yuan, Liu, Chia-Chen, Shinohara, Mitsuru, Nielsen, Henrietta M., Dong, Qiang, Kanekiyo, Takahisa, Bu, Guojun
Publicado em 2014

The Role of APOE in Cerebrovascular Dysfunction

Por Tai, Leon M, Thomas, Riya, Marottoli, Felecia M, Koster, Kevin P, Kanekiyo, Takahisa, Morris, Alan WJ, Bu, Guojun
Publicado no Acta Neuropathol (2016)

Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Mediates Neuronal Aβ42 Uptake and Lysosomal Trafficking

Por Fuentealba, Rodrigo A., Liu, Qiang, Zhang, Juan, Kanekiyo, Takahisa, Hu, Xiaoyan, Lee, Jin-Moo, LaDu, Mary Jo, Bu, Guojun
Publicado em 2010

Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan

Por Fu, Yuan, Zhao, Jing, Atagi, Yuka, Nielsen, Henrietta M., Liu, Chia-Chen, Zheng, Honghua, Shinohara, Mitsuru, Kanekiyo, Takahisa, Bu, Guojun
Publicado no Mol Neurodegener (2016)