Rescuing Effects of RXR Agonist Bexarotene on Aging-related Synapse Loss Depend on Neuronal LRP1

Apolipoprotein E (apoE) plays a critical role in maintaining synaptic integrity by transporting cholesterol to neurons through the low-density lipoprotein receptor related protein-1 (LRP1). Bexarotene, a retinoid X receptor (RXR) agonist, has been reported to have potential beneficial effects on cog...

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Veröffentlicht in:Exp Neurol
Hauptverfasser: Tachibana, Masaya, Shinohara, Mitsuru, Yamazaki, Yu, Liu, Chia-Chen, Rogers, Justin, Bu, Guojun, Kanekiyo, Takahisa
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761336/
https://ncbi.nlm.nih.gov/pubmed/26688581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2015.12.003
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