Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway

Pericytes play a critical role in the cerebrovasculature within the CNS. These small contractile cells produce large quantities of apolipoprotein E (apoE) whose isoforms influence cerebrovascular functions and determine the genetic risk for Alzheimer disease. Despite extensive studies on astrocyte-s...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Casey, Caroline S., Atagi, Yuka, Yamazaki, Yu, Shinohara, Mitsuru, Tachibana, Masaya, Fu, Yuan, Bu, Guojun, Kanekiyo, Takahisa
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2015
Ämnen:
Neurobiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447989/
https://ncbi.nlm.nih.gov/pubmed/25903128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.625251
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