Differential Regulation of Amyloid-β Endocytic Trafficking and Lysosomal Degradation by Apolipoprotein E Isoforms

Aggregation of amyloid-β (Aβ) peptides leads to synaptic disruption and neurodegeneration in Alzheimer disease (AD). A major Aβ clearance pathway in the brain is cellular uptake and degradation. However, how Aβ traffics through the endocytic pathway and how AD risk factors regulate this event is unc...

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Detaylı Bibliyografya
Asıl Yazarlar: Li, Jie, Kanekiyo, Takahisa, Shinohara, Mitsuru, Zhang, Yunwu, LaDu, Mary Jo, Xu, Huaxi, Bu, Guojun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2012
Konular:
Neurobiology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531774/
https://ncbi.nlm.nih.gov/pubmed/23132858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.420224
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