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Differential Regulation of Amyloid-β Endocytic Trafficking and Lysosomal Degradation by Apolipoprotein E Isoforms

Aggregation of amyloid-β (Aβ) peptides leads to synaptic disruption and neurodegeneration in Alzheimer disease (AD). A major Aβ clearance pathway in the brain is cellular uptake and degradation. However, how Aβ traffics through the endocytic pathway and how AD risk factors regulate this event is unc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Li, Jie, Kanekiyo, Takahisa, Shinohara, Mitsuru, Zhang, Yunwu, LaDu, Mary Jo, Xu, Huaxi, Bu, Guojun
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531774/
https://ncbi.nlm.nih.gov/pubmed/23132858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.420224
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