Retinoic Acid Isomers Facilitate Apolipoprotein E Production and Lipidation in Astrocytes through the Retinoid X Receptor/Retinoic Acid Receptor Pathway

Apolipoprotein E (apoE) is the major cholesterol transport protein in the brain. Among the three human APOE alleles (APOE2, APOE3, and APOE4), APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease (AD). The accumulation of amyloid-β (Aβ) is a central event in AD pathogenesis. I...

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Bibliographic Details
Main Authors: Zhao, Jing, Fu, Yuan, Liu, Chia-Chen, Shinohara, Mitsuru, Nielsen, Henrietta M., Dong, Qiang, Kanekiyo, Takahisa, Bu, Guojun
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Neurobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036266/
https://ncbi.nlm.nih.gov/pubmed/24599963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.526095
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