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Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan

BACKGROUND: The accumulation, aggregation and deposition of amyloid-β (Aβ) peptides in the brain are central to the pathogenesis of Alzheimer’s disease (AD). Alzheimer’s disease risk increases significantly in individuals carrying one or two copies of APOE ε4 allele compared to individuals with an ε...

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Dettagli Bibliografici
Pubblicato in:Mol Neurodegener
Autori principali: Fu, Yuan, Zhao, Jing, Atagi, Yuka, Nielsen, Henrietta M., Liu, Chia-Chen, Zheng, Honghua, Shinohara, Mitsuru, Kanekiyo, Takahisa, Bu, Guojun
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857252/
https://ncbi.nlm.nih.gov/pubmed/27151330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0099-y
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