Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan

BACKGROUND: The accumulation, aggregation and deposition of amyloid-β (Aβ) peptides in the brain are central to the pathogenesis of Alzheimer’s disease (AD). Alzheimer’s disease risk increases significantly in individuals carrying one or two copies of APOE ε4 allele compared to individuals with an ε...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Mol Neurodegener
Hlavní autoři: Fu, Yuan, Zhao, Jing, Atagi, Yuka, Nielsen, Henrietta M., Liu, Chia-Chen, Zheng, Honghua, Shinohara, Mitsuru, Kanekiyo, Takahisa, Bu, Guojun
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857252/
https://ncbi.nlm.nih.gov/pubmed/27151330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0099-y
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky