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Apolipoprotein E and Alzheimer disease: risk, mechanisms, and therapy

Apolipoprotein E (ApoE) is a major cholesterol carrier that supports lipid transport and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants of Alzheimer disease (AD) risk: individuals carrying the ε4 allele are at increased risk of AD compared with those carrying...

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Autores principales: Liu, Chia-Chen, Kanekiyo, Takahisa, Xu, Huaxi, Bu, Guojun
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726719/
https://ncbi.nlm.nih.gov/pubmed/23296339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrneurol.2012.263
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