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ApoE and Aβ in Alzheimer’s disease: accidental encounters or partners?
Among the three human apolipoprotein E (apoE) isoforms, apoE4 increases the risk of Alzheimer’s disease (AD). While transporting cholesterol is a primary function, apoE also regulates amyloid-β (Aβ) metabolism, aggregation and deposition. Although earlier work suggests that different affinities of a...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3983361/ https://ncbi.nlm.nih.gov/pubmed/24559670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.01.045 |
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