Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Mediates Neuronal Aβ42 Uptake and Lysosomal Trafficking

BACKGROUND: Alzheimer's disease (AD) is characterized by the presence of early intraneuronal deposits of amyloid-β 42 (Aβ42) that precede extracellular amyloid deposition in vulnerable brain regions. It has been hypothesized that endosomal/lysosomal dysfunction might be associated with the path...

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Detalhes bibliográficos
Main Authors: Fuentealba, Rodrigo A., Liu, Qiang, Zhang, Juan, Kanekiyo, Takahisa, Hu, Xiaoyan, Lee, Jin-Moo, LaDu, Mary Jo, Bu, Guojun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912373/
https://ncbi.nlm.nih.gov/pubmed/20686698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011884
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