Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition

Accumulation and deposition of amyloid-β (Aβ) in the brain represent an early and perhaps necessary step in the pathogenesis of Alzheimer's disease (AD). Aβ accumulation leads to the formation of Aβ aggregates, which may directly and indirectly lead to eventual neurodegeneration. While Aβ produ...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Liu, Chia-Chen, Hu, Jin, Zhao, Na, Wang, Jian, Wang, Na, Cirrito, John R., Kanekiyo, Takahisa, Holtzman, David M., Bu, Guojun
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391682/
https://ncbi.nlm.nih.gov/pubmed/28275161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3442-16.2017
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