Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition

Accumulation and deposition of amyloid-β (Aβ) in the brain represent an early and perhaps necessary step in the pathogenesis of Alzheimer's disease (AD). Aβ accumulation leads to the formation of Aβ aggregates, which may directly and indirectly lead to eventual neurodegeneration. While Aβ produ...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Liu, Chia-Chen, Hu, Jin, Zhao, Na, Wang, Jian, Wang, Na, Cirrito, John R., Kanekiyo, Takahisa, Holtzman, David M., Bu, Guojun
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391682/
https://ncbi.nlm.nih.gov/pubmed/28275161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3442-16.2017
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