Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition

Accumulation and deposition of amyloid-β (Aβ) in the brain represent an early and perhaps necessary step in the pathogenesis of Alzheimer's disease (AD). Aβ accumulation leads to the formation of Aβ aggregates, which may directly and indirectly lead to eventual neurodegeneration. While Aβ produ...

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Vydáno v:J Neurosci
Hlavní autoři: Liu, Chia-Chen, Hu, Jin, Zhao, Na, Wang, Jian, Wang, Na, Cirrito, John R., Kanekiyo, Takahisa, Holtzman, David M., Bu, Guojun
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2017
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391682/
https://ncbi.nlm.nih.gov/pubmed/28275161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3442-16.2017
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