Blood-based therapies to combat aging

Tekijä Castellano, Joseph M.
Julkaisussa Gerontology (2018)

Roles of Apolipoprotein E in Alzheimer’s Disease and Other Neurological Disorders

Tekijä Verghese, Philip B., Castellano, Joseph M., Holtzman, David M.
Julkaistu 2011

Blood-borne revitalization of the aged brain

Tekijä Castellano, Joseph M., Kirby, Elizabeth D., Wyss-Coray, Tony
Julkaisussa JAMA Neurol (2015)

CalFluors: A Universal Motif for Fluorogenic Azide Probes across the Visible Spectrum

Tekijä Shieh, Peyton, Dien, Vivian T., Beahm, Brendan J., Castellano, Joseph M., Wyss-Coray, Tony, Bertozzi, Carolyn R.
Julkaisussa J Am Chem Soc (2015)

ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

Tekijä Verghese, Philip B., Castellano, Joseph M., Garai, Kanchan, Wang, Yinong, Jiang, Hong, Shah, Aarti, Bu, Guojun, Frieden, Carl, Holtzman, David M.
Julkaistu 2013

Long-Term Cognitive Impairments and Pathological Alterations in a Mouse Model of Repetitive Mild Traumatic Brain Injury

Tekijä Luo, Jian, Nguyen, Andy, Villeda, Saul, Zhang, Hui, Ding, Zhaoqing, Lindsey, Derek, Bieri, Gregor, Castellano, Joseph M., Beaupre, Gary S., Wyss-Coray, Tony
Julkaistu 2014

Overexpression of Low Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance

Tekijä Kim, Jungsu, Castellano, Joseph M., Jiang, Hong, Basak, Jacob M., Parsadanian, Maia, Pham, Vi, Mason, Stephanie M., Paul, Steven M., Holtzman, David M.
Julkaistu 2009

Aging. Aging-induced type I interferon signaling at the choroid plexus negatively affects brain function

Tekijä Baruch, Kuti, Deczkowska, Aleksandra, David, Eyal, Castellano, Joseph M., Miller, Omer, Kertser, Alexander, Berkutzki, Tamara, Barnett-Itzhaki, Zohar, Bezalel, Dana, Wyss-Coray, Tony, Amit, Ido, Schwartz, Michal
Julkaisussa Science (2014)

In vivo assessment of behavioral recovery and circulatory exchange in the peritoneal parabiosis model

Tekijä Castellano, Joseph M., Palner, Mikael, Li, Shi-Bin, Freeman, G. Mark, Nguyen, Andy, Shen, Bin, Stan, Trisha, Mosher, Kira I., Chin, Frederick T., de Lecea, Luis, Luo, Jian, Wyss-Coray, Tony
Julkaisussa Sci Rep (2016)

Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis

Tekijä Castellano, Joseph M., Deane, Rashid, Gottesdiener, Andrew J., Verghese, Philip B., Stewart, Floy R., West, Tim, Paoletti, Andrew C., Kasper, Tristan R., DeMattos, Ronald B., Zlokovic, Berislav V., Holtzman, David M.
Julkaistu 2012

In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis

Tekijä Ulrich, Jason D, Burchett, Jack M, Restivo, Jessica L, Schuler, Dorothy R, Verghese, Philip B, Mahan, Thomas E, Landreth, Gary E, Castellano, Joseph M, Jiang, Hong, Cirrito, John R, Holtzman, David M
Julkaistu 2013

Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore

Tekijä Zhang, Xiaodong, Wang, Huasen, Antaris, Alexander L., Li, Lulin, Diao, Shuo, Ma, Rui, Nguyen, Andy, Hong, Guosong, Ma, Zuoran, Wang, Joy, Zhu, Shoujun, Castellano, Joseph M., Wyss-Coray, Tony, Liang, Yongye, Luo, Jian, Dai, Hongjie
Julkaisussa Adv Mater (2016)

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

Tekijä Castellano, Joseph M., Mosher, Kira I., Abbey, Rachelle J., McBride, Alisha A., James, Michelle L., Berdnik, Daniela, Shen, Jadon C., Zou, Bende, Xie, Xinmin S., Tingle, Martha, Hinkson, Izumi V., Angst, Martin S., Wyss-Coray, Tony
Julkaisussa Nature (2017)

Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

Tekijä Castellano, Joseph M., Kim, Jungsu, Stewart, Floy R., Jiang, Hong, DeMattos, Ronald B., Patterson, Bruce W., Fagan, Anne M., Morris, John C., Mawuenyega, Kwasi G., Cruchaga, Carlos, Goate, Alison M., Bales, Kelly R., Paul, Steven M., Bateman, Randall J., Holtzman, David M.
Julkaistu 2011

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

Tekijä Villeda, Saul A, Plambeck, Kristopher E, Middeldorp, Jinte, Castellano, Joseph M, Mosher, Kira I, Luo, Jian, Smith, Lucas K, Bieri, Gregor, Lin, Karin, Berdnik, Daniela, Wabl, Rafael, Udeochu, Joe, Wheatley, Elizabeth G, Zou, Bende, Simmons, Danielle A, Xie, Xinmin S, Longo, Frank M, Wyss-Coray, Tony
Julkaisussa Nat Med (2014)

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity

Tekijä Czirr, Eva, Castello, Nicholas A., Mosher, Kira I., Castellano, Joseph M., Hinkson, Izumi V., Lucin, Kurt M., Baeza-Raja, Bernat, Ryu, Jae Kyu, Li, Lulin, Farina, Sasha N., Belichenko, Nadia P., Longo, Frank M., Akassoglou, Katerina, Britschgi, Markus, Cirrito, John R., Wyss-Coray, Tony
Julkaisussa J Exp Med (2017)

Effects of the Absence of Apolipoprotein E on Lipoproteins, Neurocognitive Function, and Retinal Function

Tekijä Mak, Angel C. Y., Pullinger, Clive R., Tang, Ling Fung, Wong, Jinny S., Deo, Rahul C., Schwarz, Jean-Marc, Gugliucci, Alejandro, Movsesyan, Irina, Ishida, Brian Y., Chu, Catherine, Poon, Annie, Kim, Phillip, Stock, Eveline O., Schaefer, Ernst J., Asztalos, Bela F., Castellano, Joseph M., Wyss-Coray, Tony, Duncan, Jacque L., Miller, Bruce L., Kane, John P., Kwok, Pui-Yan, Malloy, Mary J.
Julkaisussa JAMA Neurol (2014)

Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age

Tekijä Brigger, Daniel, Riether, Carsten, van Brummelen, Robin, Mosher, Kira I., Shiu, Alicia, Ding, Zhaoqing, Zbären, Noemi, Gasser, Pascal, Guntern, Pascal, Yousef, Hanadie, Castellano, Joseph M., Storni, Federico, Graff-Radford, Neill, Britschgi, Markus, Grandgirard, Denis, Hinterbrandner, Magdalena, Siegrist, Mark, Moullan, Norman, Hofstetter, Willy, Leib, Stephen L., Villiger, Peter M., Auwerx, Johan, Villeda, Saul A., Wyss-Coray, Tony, Noti, Mario, Eggel, Alexander
Julkaisussa Nat Metab (2020)