ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

Apolipoprotein E gene (APOE) alleles may shift the onset of Alzheimer’s disease (AD) through apoE protein isoforms changing the probability of amyloid-β (Aβ) accumulation. It has been proposed that differential physical interactions of apoE isoforms with soluble Aβ (sAβ) in brain fluids influence th...

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Main Authors: Verghese, Philip B., Castellano, Joseph M., Garai, Kanchan, Wang, Yinong, Jiang, Hong, Shah, Aarti, Bu, Guojun, Frieden, Carl, Holtzman, David M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2013
Ábhair:
PNAS Plus
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651443/
https://ncbi.nlm.nih.gov/pubmed/23620513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220484110
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