The Binding of Apolipoprotein E to Oligomers and Fibrils of Amyloid-β Alters the Kinetics of Amyloid Aggregation

[Image: see text] Deposition of amyloid-β (Aβ) in Alzheimer’s disease (AD) is strongly correlated with the APOE genotype. However, the role of apolipoprotein E (apoE) in Aβ aggregation has remained unclear. Here we have used different apoE preparations, such as recombinant protein or protein isolate...

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Bibliografiske detaljer
Main Authors: Garai, Kanchan, Verghese, Philip B., Baban, Berevan, Holtzman, David M., Frieden, Carl
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196732/
https://ncbi.nlm.nih.gov/pubmed/25207746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi5008172
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