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Dissociation of apoE oligomers to monomers is required for high affinity binding to phospholipid vesicles
The apolipoprotein apoE plays a key role in cholesterol and lipid metabolism. There are three isoforms of this protein, one of which, apoE4, is the major risk factor for Alzheimer's Disease. At μM concentrations all lipid-free apoE isoforms exist primarily as monomers, dimers and tetramers. How...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3088999/ https://ncbi.nlm.nih.gov/pubmed/21322570 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1020106 |
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