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Dissociation of apoE oligomers to monomers is required for high affinity binding to phospholipid vesicles

The apolipoprotein apoE plays a key role in cholesterol and lipid metabolism. There are three isoforms of this protein, one of which, apoE4, is the major risk factor for Alzheimer's Disease. At μM concentrations all lipid-free apoE isoforms exist primarily as monomers, dimers and tetramers. How...

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Detalhes bibliográficos
Main Authors: Garai, Kanchan, Baban, Berevan, Frieden, Carl
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088999/
https://ncbi.nlm.nih.gov/pubmed/21322570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1020106
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