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Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer’s disease
Apolipoproteins E3 and E4, proteins with a molecular mass of 34.15 kDa, differ by a single amino acid change. ApoE4 contains an arginine residue at position 112, whereas apoE3 has a cysteine at this position. ApoE4 is the major risk factor for late-onset Alzheimer’s disease, whereas apoE3, the commo...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3384159/ https://ncbi.nlm.nih.gov/pubmed/22615372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207022109 |
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