Overexpression of Low Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance

Apolipoprotein E (APOE) is the strongest genetic risk factor for Alzheimer’s disease (AD). Previous studies suggest that the effect of apoE on amyloid-β (Aβ) accumulation plays a major role in AD pathogenesis. Therefore, understanding proteins that control apoE metabolism may provide new targets for...

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Main Authors: Kim, Jungsu, Castellano, Joseph M., Jiang, Hong, Basak, Jacob M., Parsadanian, Maia, Pham, Vi, Mason, Stephanie M., Paul, Steven M., Holtzman, David M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787195/
https://ncbi.nlm.nih.gov/pubmed/20005821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2009.11.013
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