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Overexpression of Low Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance
Apolipoprotein E (APOE) is the strongest genetic risk factor for Alzheimer’s disease (AD). Previous studies suggest that the effect of apoE on amyloid-β (Aβ) accumulation plays a major role in AD pathogenesis. Therefore, understanding proteins that control apoE metabolism may provide new targets for...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2787195/ https://ncbi.nlm.nih.gov/pubmed/20005821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2009.11.013 |
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