Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling

BACKGROUND: Abnormal proteostasis due to alterations in protein turnover has been postulated to play a central role in several neurodegenerative diseases. Therefore, the development of techniques to quantify protein turnover in the brain is critical for understanding the pathogenic mechanisms of the...

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Bibliografiske detaljer
Main Authors: Basak, Jacob M, Kim, Jungsu, Pyatkivskyy, Yuriy, Wildsmith, Kristin R, Jiang, Hong, Parsadanian, Maia, Patterson, Bruce W, Bateman, Randall J, Holtzman, David M
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Methodology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405485/
https://ncbi.nlm.nih.gov/pubmed/22512932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-14
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