In Vivo Human Apolipoprotein E Isoform Fractional Turnover Rates in the CNS

Apolipoprotein E (ApoE) is the strongest genetic risk factor for Alzheimer’s disease and has been implicated in the risk for other neurological disorders. The three common ApoE isoforms (ApoE2, E3, and E4) each differ by a single amino acid, with ApoE4 increasing and ApoE2 decreasing the risk of Alz...

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Detalhes bibliográficos
Main Authors: Wildsmith, Kristin R., Basak, Jacob M., Patterson, Bruce W., Pyatkivskyy, Yuriy, Kim, Jungsu, Yarasheski, Kevin E., Wang, Jennifer X., Mawuenyega, Kwasi G., Jiang, Hong, Parsadanian, Maia, Yoon, Hyejin, Kasten, Tom, Sigurdson, Wendy C., Xiong, Chengjie, Goate, Alison, Holtzman, David M., Bateman, Randall J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366983/
https://ncbi.nlm.nih.gov/pubmed/22675504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038013
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