Clearance of amyloid-β by circulating lipoprotein receptors

Low-density lipoprotein receptor-related protein-1 (LRP) on brain capillaries clears amyloid β-peptide (Aβ) from brain. Here, we show that soluble circulating LRP (sLRP) provides key endogenous peripheral ‘sink’ activity for Aβ in humans. Recombinant LRP cluster IV (LRP-IV) bound Aβ in plasma in mic...

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Detalhes bibliográficos
Main Authors: Sagare, Abhay, Deane, Rashid, Bell, Robert D., Johnson, Bradley, Hamm, Katie, Pendu, Ronan, Marky, Andrew, Lenting, Peter J., Wu, Zhenhua, Zarcone, Troy, Goate, Alison, Mayo, Kevin, Perlmutter, David, Coma, Mireia, Zhong, Zhihui, Zlokovic, Berislav V
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936449/
https://ncbi.nlm.nih.gov/pubmed/17694066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1635
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