apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

Neurotoxic amyloid β peptide (Aβ) accumulates in the brains of individuals with Alzheimer disease (AD). The APOE4 allele is a major risk factor for sporadic AD and has been associated with increased brain parenchymal and vascular amyloid burden. How apoE isoforms influence Aβ accumulation in the bra...

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Detalhes bibliográficos
Main Authors: Deane, Rashid, Sagare, Abhay, Hamm, Katie, Parisi, Margaret, Lane, Steven, Finn, Mary Beth, Holtzman, David M., Zlokovic, Berislav V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582453/
https://ncbi.nlm.nih.gov/pubmed/19033669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36663
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