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Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease
APOE genotype is a major genetic risk factor for late-onset Alzheimer disease (AD). ABCA1, a member of the ATP-binding cassette family of active transporters, lipidates apoE in the CNS. Abca1(–/–) mice have decreased lipid associated with apoE and increased amyloid deposition in several AD mouse mod...
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| Autori principali: | , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2200302/ https://ncbi.nlm.nih.gov/pubmed/18202749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33622 |
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