Rapid Microglial Response Around Amyloid Pathology after Systemic Anti-Aβ Antibody Administration in PDAPP Mice

Aggregation of amyloid-β (Aβ) peptide in the brain in the form of neuritic plaques and cerebral amyloid angiopathy (CAA) is a key feature of Alzheimer's disease (AD). Microglial cells surround aggregated Aβ and are believed to play a role in AD pathogenesis. A therapy for AD that has entered cl...

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Main Authors: Koenigsknecht-Talboo, Jessica, Meyer-Luehmann, Melanie, Parsadanian, Maia, Garcia-Alloza, Monica, Finn, Mary Beth, Hyman, Bradley T., Bacskai, Brian J., Holtzman, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743894/
https://ncbi.nlm.nih.gov/pubmed/19109498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4147-08.2008
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