Dendritic Spine Abnormalities in Amyloid Precursor Protein Transgenic Mice Demonstrated by Gene Transfer and Intravital Multiphoton Microscopy

Accumulation of amyloid-β (Aβ) into senile plaques in Alzheimer's disease (AD) is a hallmark neuropathological feature of the disorder, which likely contributes to alterations in neuronal structure and function. Recent work has revealed changes in neurite architecture associated with plaques an...

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Detalhes bibliográficos
Main Authors: Spires, Tara L., Meyer-Luehmann, Melanie, Stern, Edward A., McLean, Pamela J., Skoch, Jesse, Nguyen, Paul T., Bacskai, Brian J., Hyman, Bradley T.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2005
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820616/
https://ncbi.nlm.nih.gov/pubmed/16079410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1879-05.2005
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