Drug Targets from Genetics: Alpha-Synuclein

ανά Danzer, Karin M., McLean, Pamela J.
Έκδοση 2011

Untangling a Role for Tau in Synucleinopathies

ανά Delenclos, Marion, Moussaud, Simon, McLean, Pamela J.
Τόπος έκδοσης Biol Psychiatry (2015)

Molecular Chaperones in Parkinson’s Disease – Present and Future

ανά Ebrahimi-Fakhari, Darius, Wahlster, Lara, McLean, Pamela J.
Έκδοση 2011

PROTEIN DEGRADATION PATHWAYS IN PARKINSON’S DISEASE – CURSE OR BLESSING

ανά Ebrahimi-Fakhari, Darius, Wahlster, Lara, McLean, Pamela J.
Έκδοση 2012

Molecular Chaperones and Co-Chaperones in Parkinson Disease

ανά Dimant, Hemi, Ebrahimi-Fakhari, Darius, McLean, Pamela J.
Έκδοση 2012

Alpha-synuclein's degradation in vivo: Opening a new (cranial) window on the roles of degradation pathways in Parkinson disease

ανά Ebrahimi-Fakhari, Darius, McLean, Pamela J, Unni, Vivek K
Έκδοση 2012

Extracellular ATP induces intracellular alpha-synuclein accumulation via P2X1 receptor-mediated lysosomal dysfunction

ανά Gan, Ming, Moussaud, Simon, Jiang, Peizhou, McLean, Pamela J.
Τόπος έκδοσης Neurobiol Aging (2014)

Targeted Overexpression of Human Alpha-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease

ανά Theodore, Shaji, Cao, Shuwen, McLean, Pamela J., Standaert, David G.
Έκδοση 2008

Biomarkers in Parkinson's disease: Advances and strategies

ανά Delenclos, Marion, Jones, Daryl R., McLean, Pamela J., Uitti, Ryan J.
Τόπος έκδοσης Parkinsonism Relat Disord (2015)

Comparison of Transduction Efficiency of Recombinant AAV Serotypes 1, 2, 5, and 8 in the Rat Nigrostriatal System

ανά McFarland, Nikolaus R., Lee, Jeng-Shin, Hyman, Bradley T., McLean, Pamela J.
Έκδοση 2009

Characterization of Oligomer Formation of Amyloid-β Peptide Using a Split-luciferase Complementation Assay

ανά Hashimoto, Tadafumi, Adams, Kenneth W., Fan, Zhanyun, McLean, Pamela J., Hyman, Bradley T.
Έκδοση 2011

Commentary: alpha-synuclein interacts with SOD1 and promotes its oligomerization

ανά Helferich, Anika M., McLean, Pamela J., Weishaupt, Jochen H., Danzer, Karin M.
Τόπος έκδοσης J Neurol Neuromedicine (2016)

Bimolecular Fluorescence Complementation of Alpha-synuclein Demonstrates its Oligomerization with Dopaminergic Phenotype in Mice

ανά Cai, Waijiao, Feng, Danielle, Schwarzschild, Michael A., McLean, Pamela J., Chen, Xiqun
Τόπος έκδοσης EBioMedicine (2018)

Histones facilitate α-synuclein aggregation during neuronal apoptosis

ανά Jiang, Peizhou, Gan, Ming, Yen, Shu-Hui, McLean, Pamela J., Dickson, Dennis W.
Τόπος έκδοσης Acta Neuropathol (2016)

Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates

ανά Jiang, Peizhou, Gan, Ming, Yen, Shu-Hui, McLean, Pamela J., Dickson, Dennis W.
Τόπος έκδοσης Sci Rep (2017)

Studying protein degradation pathways in vivo using a cranial window-based approach

ανά Unni, Vivek K., Ebrahimi-Fakhari, Darius, Vanderburg, Charles R., McLean, Pamela J., Hyman, Bradley T.
Έκδοση 2010

SIRT1 Protects against α-Synuclein Aggregation by Activating Molecular Chaperones

ανά Donmez, Gizem, Arun, Anirudh, Chung, Chee-Yeun, McLean, Pamela J., Lindquist, Susan, Guarente, Leonard
Έκδοση 2012

Direct Visualization of CHIP-Mediated Degradation of Alpha-Synuclein In Vivo: Implications for PD Therapeutics

ανά Dimant, Hemi, Zhu, Liya, Kibuuka, Laura N., Fan, Zhanyun, Hyman, Bradley T., McLean, Pamela J.
Έκδοση 2014

α-synuclein multimers cluster synaptic-vesicles and attenuate recycling

ανά Wang, Lina, Das, Utpal, Scott, David A., Tang, Yong, McLean, Pamela J., Roy, Subhojit
Έκδοση 2014

Targeting alpha-synuclein oligomers by protein-fragment complementation for drug discovery in synucleinopathies

ανά Moussaud, Simon, Malany, Siobhan, Mehta, Alka, Vasile, Stefan, Smith, Layton H., McLean, Pamela J.
Τόπος έκδοσης Expert Opin Ther Targets (2015)