Bimolecular Fluorescence Complementation of Alpha-synuclein Demonstrates its Oligomerization with Dopaminergic Phenotype in Mice

Alpha-synuclein (αSyn) is encoded by the first causal gene identified in Parkinson's disease (PD) and is the main component of Lewy bodies, a pathological hallmark of PD. aSyn-based animal models have contributed to our understanding of PD pathophysiology and to the development of therapeutics....

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Cai, Waijiao, Feng, Danielle, Schwarzschild, Michael A., McLean, Pamela J., Chen, Xiqun
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5925445/
https://ncbi.nlm.nih.gov/pubmed/29433982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.01.035
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