In silico modeling of the effects of alpha-synuclein oligomerization on dopaminergic neuronal homeostasis

BACKGROUND: Alpha-synuclein (ASYN) is central in Parkinson’s disease (PD) pathogenesis. Converging pieces of evidence suggest that the levels of ASYN expression play a critical role in both familial and sporadic Parkinson’s disease. ASYN fibrils are the main component of inclusions called Lewy Bodie...

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Autori principali: Ouzounoglou, Eleftherios, Kalamatianos, Dimitrios, Emmanouilidou, Evangelia, Xilouri, Maria, Stefanis, Leonidas, Vekrellis, Kostas, Manolakos, Elias S
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062111/
https://ncbi.nlm.nih.gov/pubmed/24885905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-8-54
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