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In silico modeling of the effects of alpha-synuclein oligomerization on dopaminergic neuronal homeostasis
BACKGROUND: Alpha-synuclein (ASYN) is central in Parkinson’s disease (PD) pathogenesis. Converging pieces of evidence suggest that the levels of ASYN expression play a critical role in both familial and sporadic Parkinson’s disease. ASYN fibrils are the main component of inclusions called Lewy Bodie...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4062111/ https://ncbi.nlm.nih.gov/pubmed/24885905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-8-54 |
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