Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

BACKGROUND: The mechanisms through which aberrant α-synuclein (ASYN) leads to neuronal death in Parkinson's disease (PD) are uncertain. In isolated liver lysosomes, mutant ASYNs impair Chaperone Mediated Autophagy (CMA), a targeted lysosomal degradation pathway; however, whether this occurs in...

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Главные авторы: Xilouri, Maria, Vogiatzi, Tereza, Vekrellis, Kostas, Park, David, Stefanis, Leonidas
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2009
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677735/
https://ncbi.nlm.nih.gov/pubmed/19436756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005515
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