Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

BACKGROUND: The mechanisms through which aberrant α-synuclein (ASYN) leads to neuronal death in Parkinson's disease (PD) are uncertain. In isolated liver lysosomes, mutant ASYNs impair Chaperone Mediated Autophagy (CMA), a targeted lysosomal degradation pathway; however, whether this occurs in...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Xilouri, Maria, Vogiatzi, Tereza, Vekrellis, Kostas, Park, David, Stefanis, Leonidas
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677735/
https://ncbi.nlm.nih.gov/pubmed/19436756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005515
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares