Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

α-Synuclein (ASYN) is crucial in Parkinson disease (PD) pathogenesis. Increased levels of wild type (WT) ASYN expression are sufficient to cause PD in humans. The manner of post-transcriptional regulation of ASYN levels is controversial. Previously, we had shown that WT ASYN can be degraded by chape...

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Bibliographic Details
Main Authors: Vogiatzi, Tereza, Xilouri, Maria, Vekrellis, Kostas, Stefanis, Leonidas
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527094/
https://ncbi.nlm.nih.gov/pubmed/18566453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801992200
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