Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats

Chaperone-mediated autophagy (CMA) involves the selective lysosomal degradation of cytosolic proteins such as SNCA (synuclein α), a protein strongly implicated in Parkinson disease (PD) pathogenesis. However, the physiological role of CMA and the consequences of CMA failure in the living brain remai...

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Vydáno v:Autophagy
Hlavní autoři: Xilouri, Maria, Brekk, Oeystein Roed, Polissidis, Alexia, Chrysanthou-Piterou, Margarita, Kloukina, Ismini, Stefanis, Leonidas
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2016
Témata:
Translational Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5103347/
https://ncbi.nlm.nih.gov/pubmed/27541985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1214777
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