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Aberrant Interaction between Parkinson Disease-associated Mutant UCH-L1 and the Lysosomal Receptor for Chaperone-mediated Autophagy
Parkinson disease (PD) is the most common neurodegenerative movement disorder. An increase in the amount of α-synuclein protein could constitute a cause of PD. α-Synuclein is degraded at least partly by chaperone-mediated autophagy (CMA). The I93M mutation in ubiquitin C-terminal hydrolase L1 (UCH-L...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3259779/ https://ncbi.nlm.nih.gov/pubmed/18550537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801918200 |
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